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Literature summary extracted from
- HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity (2009), Biochim. Biophys. Acta, 1793, 378-387.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.22.52 | acetyl-calpastatin peptide | 50 microM | Rattus norvegicus | |
| 3.4.22.52 | lactacystin | 1 microM | Rattus norvegicus |  |
| 3.4.22.52 | MG115 | inhibitory effect in micromolar concentrations, 1 mircoM | Rattus norvegicus | |
| 3.4.22.52 | MG132 | inhibitory effect in micromolar concentrations, 1 microM | Rattus norvegicus | |
| 3.4.22.52 | N-acetyl-Leu-Leu-norleucinal | 2-fold increase in Tat levels after pre-treating with ALLN, 10 microM | Rattus norvegicus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.22.52 | Ca2+ | - |
Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.22.52 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.22.52 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.22.52 | neuronal cell line | progenitor HCN-A94-2 | Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.52 | RecTat101 + H2O | - |
Rattus norvegicus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.22.52 | calpain 1 | - |
Rattus norvegicus |
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